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Programming of synthetic regulatory DNA for cell-type targeting in humans
Leandro N Ventimiglia1, Aleksej Zelezniak2
1Randall Centre for Cell & Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, UK.
Molecular Cell
|January 17, 2025
Abstract:
In a recent study in Nature, Gosai et al.1 introduce a framework to engineer and validate synthetic DNA regulatory elements showing cell-type-specific activity in human cell lines, closing the distance to the machine-driven design of functional regulatory sequences with therapeutic applications in humans.

