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Genetic Screens

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...

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Updated: May 1, 2026

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Published on: May 30, 2019

Genome-scale, functional screen of Plasmodium sexual replication.

Surendra K Prajapati¹, Kim C Williamson²

¹Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.

Trends in Parasitology

|January 17, 2025

Summary

Researchers screened over 300 genes crucial for malaria parasite transmission in mosquitoes. This study identifies new targets for developing innovative malaria control strategies and treatments.

Keywords:

SUN1 axoneme fertilization gametogenesis malaria transmission mitochondria

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Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

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Published on: May 30, 2019

Plasmodium falciparum Gametocyte Culture and Mosquito Infection Through Artificial Membrane Feeding

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Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

Area of Science:

Genetics
Parasitology
Infectious Diseases

Background:

Malaria causes over 500,000 deaths annually, highlighting an urgent need for novel control methods.
Effective malaria control requires targeting the parasite's complex life cycle, including its transmission stages.

Purpose of the Study:

To identify genes essential for Plasmodium sexual replication and mosquito transmission using a large-scale functional screen.
To discover new molecular targets for developing next-generation malaria interventions.

Main Methods:

Conducted a genome-scale functional screen focusing on Plasmodium sexual replication.
Analyzed gene essentiality for parasite development and transmission within the mosquito vector.

Main Results:

Identified over 300 genes critical for malaria parasite transmission through the mosquito.
The screen provided a comprehensive dataset of genes involved in parasite sexual stages.

Conclusions:

The identified genes represent promising candidates for novel malaria drug and vaccine development.
This research significantly advances our understanding of malaria parasite biology and transmission.