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Updated: Jun 1, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer

Nan Zhang1, Xinjia Wang1, Yu Li1

  • 1Shengjing Hospital of China Medical University, Obstetrics and Gynecology Department, NO36. Sanhao Street, Heping district, Shenyang, China.

Communications Biology
|January 17, 2025
PubMed

Insights

Circular RNAs (circRNAs) interact with RNA-binding proteins (RBPs) to regulate gene expression in cancer. Understanding these circRNA-protein interactions (CPIs) is key to developing novel anti-cancer therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are a class of non-coding RNAs with regulatory roles in eukaryotes.
  • RNA-binding proteins (RBPs) are critical in cancer progression, influencing tumorigenesis, metastasis, and drug response.
  • circRNA-protein interactions (CPIs) are increasingly recognized for their impact on gene expression and cancer development.

Purpose of the Study:

  • To review recent advances in circRNA-protein interactions (CPIs) in cancer.
  • To discuss the functions and mechanisms of CPIs across gene expression stages.
  • To explore the role of CPIs in tumor drug resistance and potential therapeutic applications.

Main Methods:

  • Literature review of recent research on circRNA-protein interactions.
  • Analysis of studies detailing CPI functions in cancer gene expression.
  • Examination of evidence linking CPIs to cancer drug resistance.

Main Results:

  • CPIs influence gene expression at transcriptional, splicing, translational, and post-translational levels.
  • circRNAs modulate RBP activity, affecting tumor initiation, progression, and metastasis.
  • CPIs play a significant role in the development of tumor drug resistance.

Conclusions:

  • circRNA-protein interactions are crucial regulators in cancer biology.
  • Understanding CPIs offers potential for developing new anti-cancer therapeutic strategies.
  • Targeting CPIs may overcome drug resistance and improve cancer treatment outcomes.

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