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Abnormal sensory processing cortex in insomnia disorder: a degree centrality study.

Hui Wang1,2, Haining Li3, Ziyi Liu2

  • 1School of Future Technology, Xi'an Jiaotong University, Xi'an, 710049, China.

Brain Imaging and Behavior
|January 17, 2025
PubMed
Summary
This summary is machine-generated.

Insomnia disorder involves altered brain network centrality, particularly in sensory and emotional processing regions. These brain changes correlate with sleep quality and depression symptoms, offering insights into insomnia

Keywords:
Degree centralityFunctional magnetic resonance imagingInsomnia disorderSensory cortexThalamus

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Sleep Medicine

Background:

  • Insomnia disorder is a prevalent global health issue.
  • Understanding its pathogenesis is crucial for effective treatment.
  • Brain network dysfunction is increasingly implicated in insomnia.

Purpose of the Study:

  • To investigate the pathogenesis of insomnia disorder using voxel-level static and dynamic degree centrality.
  • To compare brain centrality measures between insomnia patients and healthy controls.
  • To explore correlations between altered centrality and clinical indicators of insomnia.

Main Methods:

  • Employed static and dynamic degree centrality analysis at the voxel level.
  • Included 29 insomnia disorder patients and 28 healthy controls.
  • Correlated degree centrality values with the Pittsburgh Sleep Quality Index and Hamilton Depression Scale.

Main Results:

  • Insomnia patients showed higher static degree centrality in sensory processing areas (occipital gyrus, inferior temporal gyrus) and lower centrality in subcortical regions (amygdala, thalamus).
  • Dynamic degree centrality alterations were observed in the default mode network and salience network regions.
  • Negative correlation between dynamic centrality (inferior parietal gyrus) and sleep quality; positive correlation between static centrality (inferior temporal gyrus) and depression severity.

Conclusions:

  • Dysfunctional brain network centrality in sensory and subcortical regions is linked to sleep-wake imbalance in insomnia.
  • Altered network dynamics in default mode and salience networks contribute to insomnia neuropathogenesis.
  • Findings support hyperarousal mechanisms and offer novel perspectives on insomnia's neural underpinnings.