Factors of progression to severity and death in COVID-19 patients at two health care sites in Bamako, Mali
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View abstract on PubMed
Summary
This summary is machine-generated.Older age, higher heart rate, and respiratory distress significantly increase COVID-19 mortality risk. Younger age and azithromycin treatment were found to be protective factors in Bamako patients.
Area Of Science
- Epidemiology
- Infectious Diseases
- Public Health
Background
- COVID-19 poses a significant global health threat, with varying mortality rates influenced by clinical and biological factors.
- Understanding specific risk factors for mortality is crucial for targeted interventions, especially in diverse healthcare settings.
Purpose Of The Study
- To analyze the clinical and biological characteristics of COVID-19 patients.
- To identify risk factors associated with mortality among COVID-19 patients in Commune IV, Bamako.
Main Methods
- A cohort study of 1319 COVID-19 patients managed between March 2020 and June 2022.
- Sociodemographic, clinical, and biological data were collected and analyzed.
- Binomial logistic regression models were employed to determine mortality-associated risk factors.
Main Results
- The case fatality rate was 3.71%. Predominant symptoms included cough, respiratory difficulty, and headache.
- Factors associated with death in bivariate analysis were older age, hypertension, diabetes, clinical severity, and low D-dimer levels.
- Logistic regression identified older age, increased heart rate, and acute respiratory distress syndrome as significant risk factors for mortality. Younger age and azithromycin were protective.
Conclusions
- Advanced age, elevated heart rate, and respiratory distress are key factors linked to increased COVID-19 fatalities.
- Findings highlight factors influencing severity and lethality, independent of healthcare system constraints.
- Identifying protective factors like younger age and azithromycin treatment can inform clinical management strategies.
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