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Related Experiment Video

Updated: Jun 1, 2025

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
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Undifferentiated pleomorphic sarcoma in the maxillary sinus: a case report.

Seyed Hosein Tabatabaei1, Alireza Navabazam2, Mohammad Amin Yektaie2

  • 1Department of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Journal of Medical Case Reports
|January 17, 2025
PubMed
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Maxillary chondrosarcoma: a case report.

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Undifferentiated pleomorphic sarcoma is a rare malignancy in the maxillary sinus. Accurate diagnosis is crucial, as it can be mistaken for other conditions, requiring thorough histopathological examination.

Area of Science:

  • Oncology
  • Oral Pathology
  • Maxillofacial Surgery

Background:

  • Undifferentiated pleomorphic sarcoma (UPS), formerly malignant fibrous histiocytoma, is a rare soft tissue sarcoma.
  • It is infrequently found in the oral cavity and exceptionally rare in the maxillary sinus.
  • Microscopic diagnosis in the maxillary sinus is challenging due to overlapping features with other neoplasms.

Purpose of the Study:

  • To report a rare case of undifferentiated pleomorphic sarcoma in the maxillary sinus.
  • To highlight diagnostic challenges and potential errors in identifying this malignancy.
  • To emphasize the importance of comprehensive histopathological evaluation.

Main Methods:

  • Case report of a 61-year-old male with maxillary sinus mass.
Keywords:
Diagnostic challengeMalignant fibrous histiocytomaMaxillary sinusUndifferentiated pleomorphic sarcoma

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  • Initial diagnosis of peripheral giant cell granuloma via incisional biopsy.
  • Re-evaluation of slides using immunohistochemical methods led to the diagnosis of undifferentiated pleomorphic sarcoma.

    • Main Results:

    • A case of undifferentiated pleomorphic sarcoma was diagnosed in the maxillary sinus after initial misdiagnosis.
    • Immunohistochemistry was critical in differentiating UPS from other potential diagnoses.
    • The patient presented with symptoms of facial pain, swelling, and visual disturbances.

    Conclusions:

    • Undifferentiated pleomorphic sarcoma in the maxillary sinus presents diagnostic difficulties.
    • Histopathological diagnostic errors can occur, necessitating careful review.
    • Accurate diagnosis requires a detailed and complete examination to distinguish it from other tumors.