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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Functional neurological disorder in multiple sclerosis: A prospective study.

Sofia Cuoco1, Sara Scannapieco2, Francesca Barra1

  • 1Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.

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This summary is machine-generated.

Functional Neurological Disorder (FND) affects 5.8% of Multiple Sclerosis (MS) patients, particularly those admitted for suspected relapses. Recognizing FND in MS is crucial for effective treatment and management.

Keywords:
Conversion disorderDepressionMood disordersPseudo-relapsesPsychogenic

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Area of Science:

  • Neurology
  • Neuroscience
  • Psychiatry

Background:

  • Functional Neurological Disorder (FND) is increasingly recognized as comorbid with other neurological conditions.
  • Limited data exists on FND prevalence and characteristics in Multiple Sclerosis (MS) patients.

Purpose of the Study:

  • To systematically evaluate the presence of FND in consecutive MS patients.
  • To identify clinical correlates associated with comorbid FND in MS.

Main Methods:

  • A structured protocol was used to collect demographic and clinical data from 310 consecutive MS patients.
  • Patients were assessed for mood disorders and evaluated by an FND expert.
  • Comparison between MS patients with and without FND was performed to find clinical correlates.

Main Results:

  • Comorbid FND was found in 5.8% of MS patients.
  • Incident FND was identified in 22.6% of MS patients admitted for suspected relapses.
  • MS patients with FND showed higher rates of mood disturbances and more frequent treatment switches.

Conclusions:

  • Functional Neurological Disorder (FND) is relatively common in Multiple Sclerosis (MS).
  • Similar phenomenological presentations necessitate proper screening for FND in MS patients.
  • Early recognition of FND has significant implications for treatment strategies in MS.