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Fibrinogen: A new player and target on the formation of pre-metastatic niche in tumor metastasis

  • 0Department of Gastroenterology, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Rd, Nanchang, Jiangxi 330006, China; The Second Clinical Medical College, Nanchang University, No. 1299 Xuefu Ave, Nanchang, Jiangxi 330031, China.
Critical Reviews in Oncology/hematology +

|

January 18, 2025

|

January 18, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Fibrinogen promotes tumor metastasis by shaping pre-metastatic niches (PMN) through immunosuppression, inflammation, angiogenesis, and extracellular matrix remodeling. Targeting fibrinogen offers new therapeutic strategies against cancer spread.

Area Of Science

  • Oncology
  • Cell Biology
  • Biochemistry

Background

  • Tumor metastasis is a major cause of cancer mortality and a significant challenge in treatment.
  • Pre-metastatic niches (PMN) are critical microenvironments that facilitate tumor cell colonization in distant organs.
  • Fibrinogen, a blood clotting factor, is increasingly recognized for its role in tumor metastasis and the tumor microenvironment.

Purpose Of The Study

  • To elucidate the mechanisms by which fibrinogen promotes tumor metastasis.
  • To explore the role of fibrinogen in the development of pre-metastatic niches (PMN).
  • To discuss the therapeutic potential of targeting fibrinogen for anti-metastasis strategies.

Main Methods

  • Review of existing literature on fibrinogen and tumor metastasis.
  • Analysis of fibrinogen's involvement in PMN formation from four key perspectives.
  • Discussion of potential therapeutic targets related to fibrinogen.

Main Results

  • Fibrinogen significantly contributes to the formation and development of PMN.
  • Fibrinogen influences PMN through immunosuppression, inflammation, angiogenesis, and extracellular matrix remodeling.
  • Evidence suggests fibrinogen is a key mediator in promoting tumor spread.

Conclusions

  • Fibrinogen plays a multifaceted role in shaping the pre-metastatic niche, thereby promoting tumor metastasis.
  • Understanding fibrinogen's mechanisms in PMN development is crucial for effective cancer treatment.
  • Targeting fibrinogen presents a promising therapeutic avenue to combat cancer metastasis.

Keywords:

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