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Aberrant fumarate metabolism links interferon release in diffuse systemic sclerosis

Thomas Steadman1, Steven O'Reilly1

  • 1Biosciences Department, Durham University, Durham, United Kingdom.

Journal of Dermatological Science
|January 18, 2025
PubMed
Summary

Fumarate metabolism is altered in Systemic Sclerosis (SSc), linking it to elevated Type I interferon. Mitochondrial dysfunction and DNA release contribute to this aberrant interferon response in SSc patients.

Keywords:
CGASDNAFibrosisFumarate hydrataseInterferonSTINGSystemic sclerosis

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