Endolift® is a non-surgical treatment for skin tissue conditions. Is there evidence for its application?

The Endolift® technique, introduced in 2005, gained popularity among medical and non-medical professionals as a non-surgical approach using subdermal laser devices. However, its widespread adoption lacked a thorough understanding of its physiological interaction, resulting in controversies over its effectiveness and safety. This study aimed to assess the evidence of Endolift® efficacy, parametrization, and safety by analyzing adverse events. A systematic literature review was conducted by searching the following databases: NCBI/PubMed, Medline, Embase, CINAHL, and the Cochrane Central Library. These searches resulted in 111 articles. Seven articles were selected after removing duplicates and screening titles, abstracts, and full texts. These articles exhibited a high risk of bias, a lack of standardization in treatment parameters, and reports of adverse events that did not align with clinical reality, often occurring with off-label use.In conclusion, due to insufficient high-quality research and inconsistent indications and parameter adjustments, asserting the efficacy and safety of Endolift® is challenging. Randomized studies are recommended to curb indiscriminate use, which may compromise patient safety. This analysis underscores the importance of evidence-based clinical practices for patient safety and ethical treatment.