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Microbial molecules, metabolites, and malignancy.

Ryan M Thomas1

  • 1Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL, USA.

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|January 19, 2025
PubMed
Summary
This summary is machine-generated.

The human microbiome influences cancer development and treatment through microbial metabolites. This review explores how these molecules, from bacteria and other microbes, impact various cancers.

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CancerImmunityMetabolitesMicrobiomeMicrobiota

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Area of Science:

  • Microbiology
  • Oncology
  • Metabolomics

Background:

  • Microbiome research has expanded from colon cancer to nearly all malignancies.
  • Focus is shifting from association to causation, particularly microbial metabolites' roles.

Purpose of the Study:

  • To review current research on microbial metabolites' impact on carcinogenesis.
  • To explore how these metabolites affect cancer progression and treatment response.

Main Methods:

  • Review of contemporary research literature.
  • Focus on mechanisms of microbial metabolites in cancer.

Main Results:

  • Microbial metabolites can be produced by bacteria, fungi, archaea, or from dietary/host molecules.
  • Examples often highlight bacterial metabolites in colon cancer, but research is expanding to other cancers and non-bacterial metabolites.

Conclusions:

  • Microbial metabolites play a significant role in cancer development and treatment efficacy.
  • Further research into diverse microbial metabolites and their mechanisms across various cancers is warranted.