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Therapeutic strategies and landscape of metaplastic breast cancer

Peilin Dai1, Tianyi Song2, Junzhi Liu2

  • 1Breast Center, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China; West China School of Medicine/West China Hospital, Sichuan University, Chengdu 610041, PR China.

Cancer Treatment Reviews
|January 19, 2025
PubMed

Insights

Metaplastic breast cancer is rare and resistant to standard treatments. Novel targeted therapies and immunotherapies show promise for improving patient outcomes.

Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Metaplastic breast cancer (MBC) is a rare, aggressive subtype.
  • MBC exhibits unique biological and morphological features.
  • Standard treatments are often ineffective for MBC, leading to poor prognosis.

Purpose of the Study:

  • To review current literature on metaplastic breast cancer treatment.
  • To summarize existing local and systemic therapeutic approaches.
  • To explore novel therapeutic targets and strategies for MBC.

Main Methods:

  • Comprehensive literature review of metaplastic breast cancer treatments.
  • Analysis of pathological and molecular characteristics.
  • Discussion of emerging therapeutic modalities.

Main Results:

  • Current treatment strategies for MBC are underexplored.
  • MBC demonstrates resistance to conventional therapies.
  • Pathological and molecular insights guide new treatment development.

Conclusions:

  • Targeted therapy and immunotherapy offer personalized treatment avenues for MBC.
  • These novel strategies hold potential for improving MBC patient prognosis.
  • Further research is crucial to optimize therapeutic approaches for this rare cancer.
Keywords:
ImmunotherapyMetaplastic breast cancerNovel strategiesTargeted therapyTreatment

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