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Updated: Jun 1, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Five new bisabolane-type sesquiterpenoids with oxygen-containing heterocyclic systems from Curcuma longa
Ou Dai1, Guang-Xu Wu2, Hong-Zhen Shu2
1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, China.
Abstract:
Five new bisabolane-type sesquiterpenoids (1-5) were isolated from the rhizomes of Curcuma longa, and all of them were oxygen-containing heterocyclic compounds. The structures of the compounds were elucidated using comprehensive spectroscopic techniques, and their absolute configurations were confirmed through electronic circular dichroism (ECD) calculations. All of the compounds were evaluated for their vasorelaxant and anti-inflammatory activities. The results showed that only compound 4 exhibited a vasorelaxant effect against KCl-induced contraction of rat aortic rings, and it achieved a diastolic ratio that exceeded 25 % at a concentration of 25 μM.
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