A prospective self-controlled study on the alterations of the ocular surface and conjunctival transcriptomic profile associated with prolonged exposure to video display terminals
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View abstract on PubMed
Summary
This summary is machine-generated.Prolonged video display terminal (VDT) use significantly worsens dry eye symptoms and signs, increasing the dry eye diagnosis rate and causing ocular surface inflammation. This highlights the negative impact of extended screen time on eye health.
Area Of Science
- Ophthalmology
- Ocular Surface Disease
- Digital Health
Background
- Digital devices are ubiquitous in modern life.
- Prolonged use of video display terminals (VDTs) may affect ocular surface health.
- Understanding the impact of VDTs on eye homeostasis is crucial.
Purpose Of The Study
- To investigate the effects of extended video display terminal (VDT) exposure on ocular surface homeostasis.
- To quantify changes in dry eye symptoms and clinical signs associated with increased VDT use.
Main Methods
- 30 participants reduced VDT use to <3 hours/day for one week, then increased to >8 hours/day for three weeks.
- Weekly assessments included the Ocular Surface Disease Index (OSDI) questionnaire and clinical eye examinations.
- Eyelid and meibomian gland evaluations and ocular surface transcriptomic analysis were performed.
Main Results
- Dry eye diagnosis increased from 6.67% to 51.67% with prolonged VDT use.
- Significant worsening of OSDI scores, reduced tear film stability (FBUT), and increased ocular staining (CFS, LCjs) were observed.
- Transcriptomic analysis revealed inflammatory and hormonal gene expression changes, with MUC5AC and TFF1 gene expression correlating with symptom severity.
Conclusions
- Intense and prolonged VDT exposure significantly impairs ocular surface homeostasis.
- Increased screen time leads to detrimental changes in eye surface symptoms, signs, and gene expression.
- Findings underscore the need for strategies to mitigate VDT-induced ocular surface disease.
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