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Updated: Jun 1, 2025

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
Published on: December 16, 2013
The regulatory network that controls lymphopoiesis
Luis Mendoza1, Ricardo Vázquez-Ramírez1, Juan Manuel Tzompantzi-de-Ita1
1Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, 3er Circuito Exterior s/n, Ciudad Universitaria, 04510, CdMx, México.
Abstract:
Lymphopoiesis is the generation of the T, B and NK cell lineages from a common lymphoid-biased haematopoietic stem cell. The experimental study of this process has generated a large amount of cellular and molecular data. As a result, there is a considerable number of mathematical and computational models regarding different aspects of lymphopoiesis. We hereby present a regulatory network consisting of 95 nodes and 202 regulatory interactions among them. The network is studied as a qualitative dynamical system, which has as stationary states the molecular patterns reported for CLP, pre-B, B naive, PC, pNK, iNK, NK, DP, CD8 naive, CTL, CD4 naive, Th1, Th2, Th17 and Treg cells. Also, we show that the system is able to respond to specific stimuli to reproduce the ontogeny of the T, B and NK cell lineages.
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