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Published on: March 24, 2023
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[Advances in inflammaging in liver disease]
Yanping Xu1, Luyi Chen2, Weili Liu2
1Department of General Practice, Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China. yanpingxu@zju.edu.cn.
Summary
Inflammaging, or chronic inflammation linked to aging, drives liver diseases like viral hepatitis, fatty liver, and tumors. Understanding its mechanisms offers new therapeutic targets for liver health.
Area of Science:
- Hepatology
- Immunology
- Aging Research
Background:
- Inflammaging, a hallmark of aging, involves chronic, low-grade inflammation contributing to cellular dysfunction.
- This process is increasingly recognized as a key driver in the pathogenesis and progression of various liver diseases.
Purpose of the Study:
- To elucidate the intricate mechanisms of inflammaging across different liver pathologies.
- To highlight emerging therapeutic strategies targeting inflammaging for liver disease management.
Main Methods:
- Review of current literature on inflammaging in viral hepatitis, non-alcoholic fatty liver disease, and liver tumors.
- Analysis of molecular and cellular pathways involved in inflammaging.
Main Results:
- Viral hepatitis involves oxidative stress, apoptosis, necrosis, and gut dysbiosis.
- NAFLD mechanisms include insulin resistance, fat deposition, lipid disorders, gut dysbiosis, and NAD+ metabolism abnormalities.
- Liver tumors exhibit weakened tumor suppression, microenvironment remodeling, metabolic reprogramming, and immune evasion.
Conclusions:
- Inflammaging is a central mechanism in liver disease development and progression.
- Targeting inflammaging through antioxidants, metabolic interventions, and immunotherapy shows promise for treating liver diseases.
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