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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

181
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
181
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

115
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
115
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

314
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
314
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

134
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
134
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

386
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
386
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

109
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
109

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Related Experiment Video

Updated: Jun 1, 2025

Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing
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Histological healing in IBD: Ready for prime time?

Vincenzo Villanacci1, Rachele Del Sordo2, Sara Mino1

  • 1Institute of Pathology, ASST Spedali Civili and University of Brescia, Brescia, Italy.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|January 19, 2025
PubMed
Summary

Achieving mucosal healing is key for treating ulcerative colitis and Crohn's disease. Simplified histological scoring and new biomarkers like claudin-2 aim to standardize this assessment for better patient outcomes.

Keywords:
Crohn's diseaseHistological scoresMicroscopic activityNeutrophilsUlcerative colitis

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Area of Science:

  • Gastroenterology
  • Histopathology
  • Inflammatory Bowel Disease (IBD)

Background:

  • Mucosal healing is the primary treatment goal for ulcerative colitis and Crohn's disease.
  • Current definitions integrate endoscopic and histological remission, but histological assessment can be subjective.
  • Neutrophil presence and activity are critical indicators for histological remission.

Purpose of the Study:

  • To review current definitions and challenges in assessing mucosal healing in IBD.
  • To explore simplified histological scoring systems for daily diagnostic use.
  • To highlight emerging technologies and biomarkers for standardized assessment.

Main Methods:

  • Review of literature on mucosal healing definitions and assessment methods in IBD.
  • Analysis of existing and proposed histological scoring systems.
  • Discussion of novel approaches including artificial intelligence and biomarkers.

Main Results:

  • Histological remission assessment is complex and often subjective.
  • Simplified scoring systems focusing on neutrophils show promise.
  • Artificial intelligence and biomarkers like claudin-2 are emerging tools.

Conclusions:

  • Standardizing histological assessment of mucosal healing is crucial for effective IBD management.
  • Simplified scoring and new biomarkers may improve objectivity and routine application.
  • Further research is needed to validate these novel approaches.