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Trajectory of Cardiogenic Dementia: A New Perspective

Nawaf AlRawili1, Hayder M Al-Kuraishy2, Ali I Al-Gareeb3

  • 1Department of Internal Medicine, College of Medicine, Northern Border University, Arar, Saudi Arabia.

Journal of Cellular and Molecular Medicine
|January 19, 2025
PubMed

Insights

The heart and brain are linked via the heart-brain axis. Heart disease can impair cognitive function, increasing dementia risk, with mechanisms still under investigation.

Area of Science:

  • Cardiology
  • Neurology
  • Neuroscience

Background:

  • The heart-brain axis describes the intricate connection between the heart and brain.
  • Cardiac function and cerebral blood flow are vital for brain metabolism and function.
  • Deterioration in heart health can negatively impact cognitive abilities and elevate dementia risk.

Purpose of the Study:

  • To explore the potential mechanisms underlying cardiogenic dementia.
  • To review the link between cardiac diseases and cognitive impairment.

Main Methods:

  • Literature review of studies on heart disease and cognitive function.
  • Analysis of existing research on the heart-brain axis and dementia pathogenesis.

Main Results:

  • Cognitive impairment affects 29% of heart failure patients.
  • Coronary artery disease (CAD) is linked to cognitive decline.
  • Reduced cardiac function and cerebral blood flow increase dementia risk.

Conclusions:

  • Cardiac diseases like heart failure, myocardial infarction, and atrial fibrillation contribute to cognitive deterioration.
  • Mechanisms linking cardiac dysfunction to dementia require further elucidation.
  • Understanding these mechanisms is crucial for preventing and treating cardiogenic dementia.

Keywords:
cardiogenic dementiacognitive impairmentheart failuremyocardial infarction and atrial fibrillation

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