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Prognostic significance of neutrophil extracellular trap-related genes in childhood acute lymphoblastic leukemia: insights from multi-omics and in vitro experiment

  • 0Department of Pediatrics, Peking University First Hospital Ningxia Women and Children's Hospital (Ningxia Hui Autonomous Region Maternal and Child Health Hospital), Yinchuan, People's Republic of China.
Hematology (amsterdam, Netherlands) +

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January 20, 2025

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January 20, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This study developed a prognostic model for childhood acute lymphoblastic leukemia (cALL) using extracellular trap-related genes (NETRGs). The model identified key genes that predict patient survival and may offer new therapeutic targets.

Area Of Science

  • Oncology
  • Genetics
  • Bioinformatics

Background

  • Childhood acute lymphoblastic leukemia (cALL) requires improved prognostic tools.
  • Extracellular trap-related genes (NETRGs) are implicated in various cancers.

Purpose Of The Study

  • To develop and validate a prognostic model for cALL based on NETRGs.
  • To identify novel therapeutic targets for cALL.

Main Methods

  • Analysis of transcriptomic data from TARGET-ALL-P2/P3 and GSE26713/GSE130116.
  • Identification of differentially expressed NETRGs (DE-NETRGs).
  • Construction and validation of a prognostic model using regression analyses and nomogram.

Main Results

  • Seven prognostic NETRGs were identified, forming a risk model.
  • The high-risk group showed significantly lower survival rates.
  • Immune cell profiling revealed distinct populations between risk groups; specific genes were validated via RT-qPCR.

Conclusions

  • A novel prognostic model for cALL based on NETRGs was successfully developed and validated.
  • Six genes (TLR2, PTAFR, FCGR2A, RETN, S100A12, CAT) show potential as therapeutic targets for cALL.

Keywords: