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Updated: Jun 1, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
Metal-directed hierarchical superhelices from hybrid peptide foldamers
Sanjit Dey1, Souvik Roy1, DRGKoppalu R Puneeth Kumar1
1Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune, Dr Homi Bhabha Road, Pune-411008, India. hn.gopi@iiserpune.ac.in.
Abstract:
A superhelix is a three-dimensional arrangement of a helix in which the helix is coiled around a common axis. Here, we are reporting a short 12-helix of α,γ-hybrid peptides terminated by metal binding ligands, self-assembled into a right-handed superhelix around a common axis in the presence of Cd(II) ions. Furthermore, these superhelices are assembled into hierarchical superhelical β-sheet-type structural motifs in single crystals. The results reported here may give new insights to construct advanced self-assembled architectures from peptide foldamers.
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