Preparing and Characterizing of Xyloglucan Films Containing Tea Extract for Oral Mucositis

This study aimed to prepare films using Xyloglucan (Xylo) and tea extract (TE) to treat aphthous stomatitis without causing discomfort. Xylo, which gelates by adding polyphenol, was used as a gelation agent, and TE, which contains epigallocatechin-3-gallate (EGCG) with antioxidant properties, was used as an active pharmaceutical agent. Two kinds of films, hydrogel and xerogel films, were prepared by mixing various amounts of Xylo and TE. Their gelling behavior and physicochemical properties were evaluated. The sol-gel transition temperature increased with increased TE content, and the rupture strength of the films increased with increasing Xylo and TE concentrations. Rapid water absorption and high adhesiveness were observed during the reconstruction process from the xerogel to the hydrogel. The concentrations of Xylo and TE controlled the formulations' physicochemical properties and the EGCG release rate. These results concluded that the xerogel prepared by using Xylo and TE could be applied as an oral mucosal adherent film formulation.