Photopolymerizable robust lipids towards reliability and their applications

Synthetic lipids have been studied as components in membrane models and drug delivery systems. Polymerizable phospholipids, especially photosensitive ones, can form new bilayer bonds when UV light irradiates. These phospholipids have been known since the 1980s, but in the last few years, new applications have been highlighted. Its use in drug delivery systems is interesting since the photopolymerization reaction produces highly stable vesicles. Additionally, the rearrangement of the acyl chains during the photopolymerization process can be applied in the generation of pores, resulting in systems that serve for drug-controlled release. In this article, our goal was to envision earlier photopolymers' publications towards the implications of these versatile phospholipids that led to proposed systems for drug delivery and controlled release of drugs at specific sites. This review offers a broad background towards a simple, reliable, and robust platform to make its application available.