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A tactfully designed photothermal agent collaborating with ascorbic acid for boosting maxillofacial wound healing
Yuxin Qian1, Yiting Gao2, Dong Wang3
1Department of Oral Implantology, The Affiliated Stomatological Hospital of Nanjing Medical University. State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases. Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing 210029, China.
A novel nanoparticle, 4TPE-C6T-TD@AA, uses near-infrared light to kill bacteria and reduce inflammation in maxillofacial injuries. This advanced material promotes faster wound healing by enhancing collagen formation and immune response.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Wound Healing Research
Background:
- Maxillofacial injuries present complex challenges due to microbial infections, drug resistance, and impaired immune function.
- Traditional treatments are often hindered by biofilm formation and oxidative stress, complicating bacterial eradication and tissue repair.
- Developing advanced materials is crucial for effective management of these severe injuries.
Purpose of the Study:
- To design and evaluate a novel nanoparticle-based photothermal sterilization agent for maxillofacial wound infections.
- To investigate the agent's efficacy in neutralizing reactive oxygen species, modulating macrophage polarization, and eliminating bacteria.
- To assess the therapeutic potential of the agent in promoting maxillofacial wound healing in vivo.
Main Methods:
- Synthesis of 4TPE-C6T-TD@AA nanoparticles encapsulating a near-infrared photothermal agent, liposomes, and ascorbic acid.
- In vitro assessment of reactive oxygen species neutralization, macrophage polarization (M1 to M2), and antibacterial activity against Staphylococcus aureus and Escherichia coli using 808 nm laser irradiation.
- In vivo evaluation of bacterial elimination, wound healing promotion, collagen formation, and inflammatory modulation in a rat model of Staphylococcus aureus-infected maxillofacial wounds.
Main Results:
- 4TPE-C6T-TD@AA nanoparticles effectively neutralized lipopolysaccharide-induced reactive oxygen species and promoted M1 to M2 macrophage polarization.
- Photothermal treatment with 808 nm laser irradiation eliminated over 90% of Staphylococcus aureus and Escherichia coli in vitro.
- In vivo studies showed rapid bacterial clearance and significantly enhanced wound healing, evidenced by increased collagen formation and a modulated inflammatory microenvironment.
Conclusions:
- The developed 4TPE-C6T-TD@AA nanoparticles represent a promising therapeutic strategy for treating bacterial infections in maxillofacial injuries.
- The combination of photothermal sterilization, antioxidant, and immune-regulatory functions offers a multi-pronged approach to combat infection and inflammation.
- This study highlights the potential of advanced nanomaterials in improving outcomes for patients with severe maxillofacial trauma.
