Related Experiment Video
Updated: Jun 1, 2025

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach
Published on: May 23, 2025
Recalcitrant Bilateral Volar Hand Burn Contracture in a Toddler Treated With Integra and Staged Full-thickness Skin
James C Yuen1, Jennifer L Wallace2, Susan C Steelman3
1From the Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR.
Insights
This study suggests using Integra combined with full-thickness skin grafting (FTSG) can help prevent recurrent burn contractures in pediatric hands. This approach shows promise for treating challenging volar hand injuries.
Area of Science:
- Reconstructive surgery
- Pediatric burn management
- Tissue engineering
Background:
- Recurrent burn contractures on the volar hand are challenging, particularly in children.
- Integra (a dermal regeneration template) combined with skin grafting is a potential treatment.
- The utility of full-thickness skin grafting (FTSG) with Integra for these contractures requires further investigation.
Purpose of the Study:
- To evaluate the effectiveness of Integra followed by staged FTSG for recurrent bilateral volar hand burn contracture in a pediatric patient.
- To systematically review the literature on the use of Integra and skin substitutes for palmar hand contractures and wounds.
Main Methods:
- A systematic literature review was conducted on Integra and skin substitutes for palmar hand contractures and wounds.
- A case report details the treatment of a pediatric patient with recurrent bilateral burn flexion contracture using Integra followed by staged FTSG.
- Literature search identified 92 publications on volar hand defects; 10 discussed Integra, with only 2 using FTSG with Integra.
Main Results:
- The systematic review found limited previous reports on using Integra combined with FTSG for postburn volar hand flexion contractures.
- The case report describes a successful application of Integra followed by FTSG in a pediatric patient.
- Only two studies in the literature utilized FTSG in combination with Integra for volar hand defects.
Conclusions:
- The application of FTSG to vascularized Integra may offer protection against recurrent burn contractures of the palmar hand in pediatric patients.
- This case report suggests a promising approach, but further research is needed to validate the findings.
- The combination of Integra and FTSG for recurrent volar hand burn contractures has not been previously reported in the literature.
Background:
Recurrent burn contractures on the volar aspect of the hand present a formidable challenge, especially in the pediatric patient. We used Integra followed by staged full-thickness skin grafting for recurrent bilateral volar hand burn contracture in a toddler. We reviewed the literature to appraise the utility of full-thickness skin graft (FTSG) combined with Integra used for volar hand contractures.
Methods:
A systematic review of the world's literature was conducted identifying publications on the application of Integra and skin substitutes for palmar hand contractures and wounds, to include burn injuries. We describe a case of a pediatric patient with recurrent bilateral burn flexion contracture of the palm and digits treated with scar excision and application of Integra, followed by staged application of FTSG.
Results:
We identified 92 publications pertaining to volar hand defects or contractures managed with skin grafts, skin substitutes, and/or flaps. Ten articles referred to the use of Integra on volar hand wounds or contractures, and only 2 articles used FTSG instead of split-thickness skin graft in combination with Integra. Our systematic review of volar burn injuries of the hand and fingers demonstrated that the use of Integra combined with FTSG for postburn flexion contracture of the hand has not been previously reported.
Conclusions:
This case report suggests that application of FTSG instead of split-thickness skin graft to vascularized Integra offers protective value against recurrent burn contracture of the palmar hand, but more studies are needed to support our hypothesis.
Related Concept Videos
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Clinical Applications of Epidermal Stem Cells

