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Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
Published on: July 25, 2011
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Microinvasive oral squamous cell carcinoma: A management protocol
Uma Shanker Pal1, Seema Devi2, Meleti Venkata Sowmya1
1Department of Oral and Maxillofacial Surgery, King George's Medical University, Lucknow, Uttar Pradesh, India.
National Journal of Maxillofacial Surgery
|January 20, 2025
Summary
Microinvasive oral squamous cell carcinoma (MISCC) management requires careful consideration of diagnostic errors and prognostic outcomes. Early detection and precise management of potentially malignant disorders are crucial for preventing cancer transformation.
Area of Science:
- Oncology
- Oral Pathology
Background:
- Microinvasive oral squamous cell carcinoma (MISCC) is an early-stage oral cancer characterized by basement membrane breach and invasion depth up to 2mm.
- Oral potentially malignant disorders (OPMDs) are precursors to oral cancer, necessitating vigilant monitoring.
Purpose of the Study:
- To formulate a management protocol for MISCC.
- To assess the association between OPMDs and MISCC.
Main Methods:
- A comprehensive electronic and manual literature search was performed.
- 14 relevant articles were selected and evaluated based on inclusion/exclusion criteria.
- Data from selected articles were tabulated for analysis.
Main Results:
- An association between OPMDs and MISCC was observed in 12 out of 14 reviewed articles.
- Despite NCCN guidelines, 3 out of 14 MISCC cases showed lymph node metastasis.
- Recurrence and second primary tumors are significant concerns in MISCC management.
Conclusions:
- A management protocol for MISCC was developed, integrating histopathological, clinical, and radiological findings.
- Rigorous 3-year follow-up for OPMDs is recommended to prevent malignant transformation.
- A 4-8 year follow-up is advised for MISCC patients.
Keywords:
Carcinomadiagnostic errorsinvasivenessneck dissectionneoplasmsquamous cell of head and neckMore Related Videos
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