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Related Experiment Video

Updated: May 11, 2026

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

Published on: July 25, 2011

Microinvasive oral squamous cell carcinoma: A management protocol.

Uma Shanker Pal¹, Seema Devi², Meleti Venkata Sowmya¹

¹Department of Oral and Maxillofacial Surgery, King George's Medical University, Lucknow, Uttar Pradesh, India.

National Journal of Maxillofacial Surgery

|January 20, 2025

Summary

Microinvasive oral squamous cell carcinoma (MISCC) management requires careful consideration of diagnostic errors and prognostic outcomes. Early detection and precise management of potentially malignant disorders are crucial for preventing cancer transformation.

Keywords:

Carcinoma diagnostic errors invasiveness neck dissection neoplasm squamous cell of head and neck

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Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

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Area of Science:

Oncology
Oral Pathology

Background:

Microinvasive oral squamous cell carcinoma (MISCC) is an early-stage oral cancer characterized by basement membrane breach and invasion depth up to 2mm.
Oral potentially malignant disorders (OPMDs) are precursors to oral cancer, necessitating vigilant monitoring.

Purpose of the Study:

To formulate a management protocol for MISCC.
To assess the association between OPMDs and MISCC.

Main Methods:

A comprehensive electronic and manual literature search was performed.
14 relevant articles were selected and evaluated based on inclusion/exclusion criteria.
Data from selected articles were tabulated for analysis.

Main Results:

An association between OPMDs and MISCC was observed in 12 out of 14 reviewed articles.
Despite NCCN guidelines, 3 out of 14 MISCC cases showed lymph node metastasis.
Recurrence and second primary tumors are significant concerns in MISCC management.

Conclusions:

A management protocol for MISCC was developed, integrating histopathological, clinical, and radiological findings.
Rigorous 3-year follow-up for OPMDs is recommended to prevent malignant transformation.
A 4-8 year follow-up is advised for MISCC patients.