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Updated: Jun 1, 2025

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
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RAGE and its ligands in breast cancer progression and metastasis

Madalina Coser1, Bogdan Mihai Neamtu2,3, Bogdan Pop4,5

  • 1Department of Histology, Doctoral School "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania.

Oncology Reviews
|January 20, 2025
PubMed
Abstract

Insights

The receptor for advanced glycation end products (RAGE) and its ligands play a key role in breast cancer progression and metastasis. Targeting RAGE offers potential for new breast cancer therapies and prognostic biomarkers.

Area of Science:

  • Oncology
  • Molecular Biology

Background:

  • Breast cancer is a leading cause of cancer death globally.
  • The receptor for advanced glycation end products (RAGE) and its ligands are increasingly implicated in cancer progression.

Purpose of the Study:

  • To review the role of RAGE and its ligands in breast cancer growth and metastasis.
  • To assess the relationship between RAGE polymorphism and breast cancer risk.

Main Methods:

  • Scoping review of 90 articles from PubMed.
  • Meta-analysis of the RAGE rs1800624 polymorphism and breast cancer risk.

Main Results:

  • RAGE activation promotes breast cancer cell migration, growth, angiogenesis, metastasis, and drug resistance.
  • RAGE and its ligands modulate the tumor microenvironment to enhance tumor growth.
  • High RAGE expression in breast cancer correlates with poor prognosis.

Conclusions:

  • Targeting RAGE and its ligands can impair breast cancer invasion and metastasis.
  • RAGE and its ligands show potential as prognostic biomarkers and therapeutic targets for breast cancer.
Keywords:
AGEsHMGB1RAGES100breast cancerlifestylemetastasis

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