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Updated: Jun 1, 2025

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
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Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

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Immune Reconstitution Inflammatory Syndrome-Induced Thrombocytopenia in a Patient With HIV and Coccidioidomycosis

Anthea Cheng1,2, Simon Lalehzarian1,2, Hridya Harimohan2

  • 1Medical School, American University of the Caribbean, Cupecoy, SXM.

Cureus
|January 20, 2025
PubMed

Highly active antiretroviral therapy (HAART) is imperative in managing human immunodeficiency virus (HIV) infections. HAART aims to inhibit viral replication and improve immunity. Antiretroviral therapy has led to significant improvement in CD4-T cell counts and reductions in viral load, leading to improved overall immune function, increased survival, and decreased frequency of opportunistic infections. Immune reconstitution inflammatory syndrome (IRIS) is defined by a hyperinflammatory immune response within six months of initial treatment with HAART. It is caused by dysregulated inflammatory immune responses against pathogens. Herein, we discuss a rare presentation of IRIS-induced thrombocytopenia in a 20-year-old Hispanic male patient.

Keywords:
autoimmune thrombocytopeniacoccidioidomycosishiv/aidsimmune reconstitution inflammatory syndromethrombocytopenia

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