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Related Experiment Video

Updated: Jun 1, 2025

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

189

Relation between uric acid and stroke in aortic dissection.

Peiquan Li1, Shaopeng Zhang2, Tongyun Chen2

  • 1Clinical School of Thoracic and Cardiovascular, Tianjin Medical University, Tianjin, China.

Journal of Thoracic Disease
|January 20, 2025
PubMed
Summary
This summary is machine-generated.

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A higher preoperative serum uric acid to serum creatinine ratio (SUA/Scr) is linked to a lower risk of stroke after aortic dissection surgery. This ratio may help predict postoperative stroke in patients undergoing total arch replacement.

Area of Science:

  • Cardiovascular Surgery
  • Neurosurgery
  • Medical Diagnostics

Background:

  • Stroke is a significant complication following surgery for acute type A aortic dissection (ATAAD).
  • Predictive markers for postoperative stroke in ATAAD patients are crucial for risk stratification and management.
  • The relationship between preoperative serum uric acid to serum creatinine ratio (SUA/Scr) and postoperative stroke remains under investigation.

Purpose of the Study:

  • To investigate the association between preoperative SUA/Scr and the incidence of postoperative stroke in patients undergoing total arch replacement with elephant trunk implantation for ATAAD.
  • To identify SUA/Scr as a potential predictive biomarker for postoperative stroke in this patient cohort.

Main Methods:

  • Retrospective analysis of 332 ATAAD patients who underwent surgery between June 2015 and June 2023.
Keywords:
Uric acidaortic dissectionserum uric acid to serum creatinine ratio (SUA/Scr)stroke

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  • Calculation of preoperative SUA/Scr and analysis of its correlation with postoperative stroke using logistic regression.
  • Subgroup analyses and receiver operating characteristic (ROC) curve analysis to determine optimal cut-off values and confirm associations.

    • Main Results:

    • Patients with postoperative stroke exhibited lower preoperative SUA/Scr compared to those without (P=0.03).
    • Higher SUA/Scr was significantly associated with a reduced risk of postoperative stroke, even after adjusting for confounders (OR=0.66; P=0.04).
    • The association was more pronounced in male patients, those younger than 65, and specific surgical cannulation strategies (non-axillary, left femoral) and bilateral cerebral perfusion (P<0.05).

    Conclusions:

    • Elevated preoperative SUA/Scr is independently associated with a lower risk of postoperative stroke in ATAAD patients undergoing total arch replacement.
    • SUA/Scr may serve as a valuable and accessible biomarker for predicting postoperative stroke risk.
    • Further research could explore the underlying mechanisms and clinical utility of SUA/Scr in managing ATAAD patients.