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Related Experiment Video

Updated: Jun 1, 2025

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

Is lipedema a progressive disease?

Isabel Forner-Cordero^1,2, José Muñoz-Langa³

¹Lymphedema Unit, Physical Medicine and Rehabilitation Service, Hospital Universitari i Politècnic La Fe, Valencia, Spain.

Vascular Medicine (London, England)

|January 20, 2025

Summary

Lipedema is often stable, with two-thirds of patients showing no significant change in lower limb volume over time. Progression is linked to increased BMI and abdominal fat, not age.

Keywords:

leg swelling lipedema natural history volumetry

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Area of Science:

Medical Science
Chronic Disease Research
Body Composition Analysis

Background:

Lipedema's progressive nature remains unclear.
Understanding long-term changes in lipedema is crucial for patient management.
This study investigates the chronic progression of lipedema in lower limbs.

Purpose of the Study:

To describe the long-term changes in lower limb volume in patients with lipedema.
To determine the rate of progression, stability, and improvement in lipedema.
To identify factors associated with lipedema progression.

Main Methods:

Prospective cohort study of 100 lipedema patients.
Primary endpoint: Percentage of Volume Change (PVC) over average 4.6 years.
Progression defined as PVC > 10%; improvement as PVC < -10%; stability as PVC -10% to 10%.

Main Results:

Average PVC was 2.8%.
62% of patients showed stability, 28% progression, 10% improvement.
Increased BMI and waist-to-height ratio (WHtR) significantly correlated with lipedema progression (p < 0.0001).

Conclusions:

Lipedema is stable in the majority of patients.
Age is not a factor in lipedema progression.
Progression is associated with increased abdominal fat (indicated by WHtR), highlighting the link between fat gain and disease advancement.