Related Experiment Video

Updated: Jun 1, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.2K

Expression and Clinical Implications of pro-BNP and Soluble ST2 in Chronic Heart Failure

Xing Meng1, Kai Zhang1, Wan-Jie Zeng1

  • 1Clinical Laboratory, Suzhou Kowloon Hospital Affiliated with Shanghai Jiaotong University School of Medicine, Suzhou, Jiangsu, China.

British Journal of Hospital Medicine (London, England : 2005)
|January 20, 2025
PubMed

Insights

Biomarkers pro-B-type natriuretic peptide (pro-BNP) and soluble suppression of tumorigenicity 2 (sST2) show high diagnostic value for chronic heart failure (CHF). Elevated levels correlate with disease severity, aiding in early diagnosis and assessment.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Clinical Diagnostics

Background:

  • Chronic heart failure (CHF) is a significant clinical syndrome characterized by impaired cardiac function and reduced tissue perfusion.
  • Accurate early diagnosis and severity assessment are crucial for effective CHF management.
  • Investigating novel biomarkers like pro-BNP and sST2 is essential for improving CHF diagnostics.

Purpose of the Study:

  • To investigate the expression levels of pro-B-type natriuretic peptide (pro-BNP) and soluble suppression of tumorigenicity 2 (sST2) in patients with chronic heart failure (CHF).
  • To evaluate the clinical implications of pro-BNP and sST2 in the early diagnosis and severity assessment of CHF.
  • To explore the correlation of these biomarkers with cardiac function parameters.

Main Methods:

  • A study involving 146 CHF patients and 150 healthy controls.
  • Comparison of pro-BNP and sST2 levels between groups using receiver operating characteristic (ROC) curves for diagnostic value assessment.
  • Analysis of biomarker levels across different New York Heart Association (NYHA) grades and correlation with left ventricular ejection fraction (LVEF), left atrial diameter (LAD), and left ventricular end-diastolic diameter (LVEDD).

Main Results:

  • Significantly higher pro-BNP and sST2 levels were observed in CHF patients compared to healthy controls (p < 0.05).
  • ROC curve analysis indicated good diagnostic value for both pro-BNP (AUC=0.826) and sST2 (AUC=0.733) in diagnosing CHF.
  • Biomarker levels increased with NYHA grade severity and showed inverse correlations with LVEF and positive correlations with LAD and LVEDD.

Conclusions:

  • Pro-BNP and sST2 demonstrate significant diagnostic utility for chronic heart failure.
  • These biomarkers are closely associated with cardiac function and can effectively evaluate CHF severity.
  • Their use can aid in the early detection and management of patients with chronic heart failure.

Keywords:
cardiac functionchronic heart failurepro-BNPsoluble ST2

More Related Videos

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure04:20

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure

Published on: October 1, 2019

5.7K
A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs07:09

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

1.7K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
55
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
96
Heart Failure Drugs: &#946;-Blockers01:22

Heart Failure Drugs: β-Blockers

β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
314
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.3K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
378