Related Experiment Video
Updated: Jun 1, 2025

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
Published on: March 12, 2018
Perianal mass as the debut of metastatic pulmonary neoplasia
Lorena Apodaca1, Tania Pastor2, Ane Etxart2
1General and Digestive Surgery. Coloproctology Unit, Hospital Universitario Donostia, Spain.
Abstract:
A 56-year-old male smoker presented to the Emergency Department with a painful mass in the left ischiorectal fossa, which had been present for 2 months without any other symptoms. On examination, a hard, violet-colored mass was observed, with an ulcerated central area. Blood tests were normal, and the abdominal-pelvic CT scan showed multiple hypervascular intra-abdominal masses and soft tissue lesions. A biopsy was performed, revealing a poorly differentiated metastatic carcinoma. Further investigation with a brain MRI was normal, and a chest CT showed pathological lymphadenopathy and a cavitary pulmonary mass suggestive of a primary tumor.
Related Concept Videos
Assessment of the Rectum and Anus
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

