Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Glial Cells

Glial Cells

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A comparative transcriptomic analysis of mouse demyelination models and multiple sclerosis lesions.

Nature communications·2026

Same author

Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia.

Nature communications·2022

Same author

Endothelin-1 signaling maintains glial progenitor proliferation in the postnatal subventricular zone.

Nature communications·2020

Same author

Environmental enrichment ameliorates perinatal brain injury and promotes functional white matter recovery.

Nature communications·2020

Same author

The diversity and disparity of the glial scar.

Nature neuroscience·2017

Search research articles

Related Experiment Video

Updated: Jun 1, 2025

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

Cellular Senescence in Glial Cells: Implications for Multiple Sclerosis.

Elizabeth A Maupin¹, Katrina L Adams^1,2

¹Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.

Journal of Neurochemistry

|January 20, 2025

Summary

This summary is machine-generated.

Cellular senescence, a hallmark of aging, accelerates Multiple Sclerosis (MS) progression. Understanding and targeting senescent cells in the central nervous system may offer new therapeutic strategies for MS patients.

More Related Videos

Induction and Validation of Cellular Senescence in Primary Human Cells

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

Primary Cultures of Rat Astrocytes and Microglia and Their Use in the Study of Amyotrophic Lateral Sclerosis

Primary Cultures of Rat Astrocytes and Microglia and Their Use in the Study of Amyotrophic Lateral Sclerosis

Published on: June 23, 2022

Related Experiment Videos

Last Updated: Jun 1, 2025

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

Induction and Validation of Cellular Senescence in Primary Human Cells

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

Primary Cultures of Rat Astrocytes and Microglia and Their Use in the Study of Amyotrophic Lateral Sclerosis

Primary Cultures of Rat Astrocytes and Microglia and Their Use in the Study of Amyotrophic Lateral Sclerosis

Published on: June 23, 2022

Area of Science:

Neuroscience
Immunology
Cell Biology

Background:

Aging is a primary risk factor for Multiple Sclerosis (MS) disease progression.
Cellular senescence, a state of irreversible cell cycle arrest, drives aging and is implicated in neurodegenerative diseases.
Premature cellular senescence is observed in the central nervous system (CNS) of MS patients, linked to demyelination.

Purpose of the Study:

To review current evidence on cellular senescence in MS animal models and CNS glial populations.
To identify knowledge gaps regarding senescence in MS.
To explore the potential of targeting senescent cells for MS treatment.

Main Methods:

Review of existing literature on cellular senescence in MS.
Analysis of evidence from animal models of MS.
Examination of senescence markers (p16INK4A, p21) and associated factors in glial cells.

Main Results:

Demyelination in MS induces cellular senescence, characterized by specific protein expression and secreted factors.
Senescence accumulates prematurely in the CNS of MS patients.
Evidence suggests senescence exacerbates demyelination, inflammation, and inhibits myelin repair.

Conclusions:

Cellular senescence is a significant factor in MS pathology, potentially worsening disease progression.
Further research is critical to understand in vivo senescence, its functional impact on glial cells, and the therapeutic potential of senescent cell clearance.
Targeting cellular senescence presents a promising avenue for novel MS treatments.