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Triterpenoid saponins from Rubus setchuenensis roots and their anti-inflammatory activities in vitro
Yueyue Lei1, Dawei Xu1, Yuexuan Wang1
1National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Biotechnology of Chinese Traditional Medicine, College of Health Science and Engineering, Hubei University, Wuhan, 430062, China.
Abstract:
Previously undescribed triterpenoid saponins (1-8), along with eight previously reported analogues (9-16), were isolated from an EtOAc extract obtained from the roots of Rubus setchuenensis. Structures were established based on HRESIMS, 1D and 2D NMR, as well as by literature comparisons. All compounds were isolated for the first time from the genus Rubus. Compounds 3-4, 6-8, and 12-15 displayed inhibitory activities against NO production in a RAW264.7 cell inflammation model induced by LPS. Moreover, 4, 6-8, and 12-13 exhibited inhibitory effects in a LPS-induced BV-2 cell neuroinflammation model.
