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Updated: Jun 1, 2025
Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury
Published on: July 27, 2014
PLGA scaffold combined with MSCs transplantation improved neural function and brain tissue structure in rats with
Na Xu1, Zihuan Sun1, Weikang Guan2
1Department of Anatomy, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.
Abstract:
Poly (lactic-co-glycolic acid) (PLGA) is an important biomaterial for tissue defect repair, but its application in replacing missing brain tissue needs improvement. Mesenchymal stem cells (MSCs) have been used to treat various neurological diseases, but they face challenges when filling large tissue defects. The purpose of this study was to investigate the effects of PLGA combined with MSCs transplantation on brain structure and neural function in rats with traumatic brain injury (TBI), and explore its possible mechanism. The results showed that both PLGA transplantation and PLGA+MSCs transplantation could improve the brain structure and promote nerve function recovery in rats with TBI, with PLGA+MSCs transplantation being superior to PLGA transplantation. Furthermore, compared to PLGA transplantation alone, PLGA+MSCs transplantation further reduced brain injury and cell apoptosis, promoted neuron survival, and improved synaptic plasticity. Overall, the adhesion of MSCs to PLGA can enhance the therapeutic efficacy of PLGA in rats following TBI.
