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Related Experiment Video

Updated: May 6, 2026

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Developing a core outcome set for interventions in people with mild cognitive impairment: study protocol.

Victoria Grace Gabb1,2,3, Sam Harding4, Angus G K McNair5,6

  • 1ReMemBr Group, Bristol Medical School, University of Bristol, Bristol, UK victoria.gabb@bristol.ac.uk.

BMJ Open
|January 20, 2025
PubMed
Summary

Developing a core outcome set (COS) for mild cognitive impairment (MCI) is crucial due to limited guidance and interventions. This study aims to establish a standardized COS for research and clinical practice, improving care pathways for individuals with MCI.

Keywords:
AgeingCognitionDementiaMethodsNeurologyResearch Design

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Area of Science:

  • Neurology
  • Gerontology
  • Clinical Research Methodology

Background:

  • Mild cognitive impairment (MCI) lacks standardized national clinical management guidelines and therapeutic interventions.
  • Understanding patient-important outcomes is essential for improving clinical research impact and developing effective care pathways for MCI.

Purpose of the Study:

  • To develop a Core Outcome Set (COS) for adults living with mild cognitive impairment (MCI).
  • The COS will be intended for use in interventional studies and clinical practice settings to standardize outcome measurement.

Main Methods:

  • A five-stage study design will be employed: systematic literature search, qualitative interviews, evidence synthesis, a two-round Delphi survey, and consensus meetings.
  • An umbrella review of MCI interventional studies will identify outcomes, supplemented by qualitative interviews with stakeholders (patients, families, professionals).
  • Outcomes will be synthesized into a long list, followed by Delphi surveys and consensus meetings to finalize the COS.

Main Results:

  • The study is currently in the methodology development phase.
  • Ethical approval has been obtained from the London-Queen Square Research Ethics Committee.
  • Patient and public involvement are integral to the COS development process.

Conclusions:

  • The development of a COS for MCI is a critical step towards improving research consistency and clinical care.
  • Standardized outcomes will enhance the ability to evaluate interventions and develop effective management strategies for MCI.
  • Dissemination of results through publications, conferences, and public channels will ensure broad impact.