Related Experiment Video

Updated: Jan 18, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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A systematic review of Perinatal Antibiotic Stewardship - where we are, where to go?

Cristina Winteler1, Sara Ardabili2, Markus Hodel2

  • 1Faculty of Health Science and Medicine, University of Lucerne, Lucerne, Switzerland.

Journal of Perinatology : Official Journal of the California Perinatal Association
|January 20, 2025
PubMed

Insights

Reducing antibiotic use in the perinatal period is possible, as shown by 33 of 36 studies. More research is needed on antimicrobial stewardship (AMS) and its impact on maternal and infant health.

Area of Science:

  • Perinatal Medicine
  • Infectious Diseases
  • Public Health

Background:

  • The perinatal period sees high antibiotic exposure, increasing concerns about antimicrobial resistance (AMR) and long-term health.
  • Effective antimicrobial stewardship (AMS) is crucial to mitigate these risks.

Purpose of the Study:

  • To systematically review current evidence on AMS in the perinatal period (2000-2022).
  • To identify knowledge gaps for future research on perinatal antibiotic use and stewardship.

Main Methods:

  • Comprehensive systematic review of 36 studies from 2000 to 2022.
  • Included data from the Americas, Europe, Asia, and Australia, encompassing 64,798 pregnant women and 84,137 newborns.

Main Results:

  • 33 out of 36 studies reported successful reduction in antibiotic use.
  • Indicated significant potential for reducing overall antibiotic exposure in the perinatal period.

Conclusions:

  • While reduced antibiotic use is achievable, gaps exist in antepartum/intrapartum AMS and studies from low- and middle-income countries.
  • Future research should focus on prospective studies with safety, clinical, and AMR outcomes.

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