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Combined effects of natural products and exercise on apoptosis pathways in obesity-related skeletal muscle

Chun Pan1, Yiying Yang1, Zailin Zhao2

  • 1School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, Guizhou, China.

Apoptosis : an International Journal on Programmed Cell Death
|January 20, 2025
PubMed

Insights

Combining natural products like resveratrol and exercise combats muscle cell death (apoptosis) in obesity. This approach enhances muscle health, mitochondrial function, and metabolic well-being, offering a promising treatment strategy.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Metabolic Health

Background:

  • Obesity and metabolic disorders increase skeletal muscle apoptosis, contributing to insulin resistance, type 2 diabetes, and sarcopenia.
  • Apoptosis in skeletal muscle leads to degeneration, impaired insulin sensitivity, and disease progression.

Purpose of the Study:

  • To review the combined effects of natural products (resveratrol, curcumin, quercetin) and physical exercise on skeletal muscle apoptosis.
  • To explore molecular mechanisms and clinical implications for managing obesity-related muscle dysfunction.

Main Methods:

  • Literature review focusing on natural products and exercise interventions.
  • Analysis of studies investigating apoptosis pathways, particularly the Bcl-2 pathway.
  • Examination of effects on oxidative stress, mitochondrial function, and muscle regeneration.

Main Results:

  • Natural products and exercise independently reduce oxidative stress and improve mitochondrial function.
  • Combined interventions show synergistic effects, promoting mitochondrial biogenesis and reducing apoptosis.
  • Enhanced muscle regeneration and improved muscle health observed with combined strategies.

Conclusions:

  • Combining natural products with exercise offers a potent strategy to counteract obesity-induced skeletal muscle apoptosis.
  • This synergistic approach holds promise for preventing and treating metabolic disorders and preserving muscle function.
  • Targeting apoptosis pathways via combined interventions is crucial for improving overall metabolic health.
Keywords:
ApoptosisExerciseNatural productsOxidative stressSkeletal muscle

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