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Related Concept Videos

Gallbladder01:17

Gallbladder

The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins the common...
Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...

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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
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Host Index and Gallbladder Cancer: An Emerging Prognostic Biomarker.

Abhay K Kattepur1, Mufaddal Kazi2, Shraddha Patkar2

  • 1Department of Surgical Oncology, R.L. Jalappa Institute of Oncology, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, India.

Journal of Surgical Oncology
|January 21, 2025
PubMed
Summary
This summary is machine-generated.

A higher Host index (H-index) in gallbladder cancer patients predicts worse disease-free survival after curative surgery. This highlights the role of host-related biomarkers in cancer outcomes.

Keywords:
H‐indexbiomarkergallbladder cancerprognosissurvival

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Area of Science:

  • Oncology
  • Biomarkers
  • Cancer Prognostics

Background:

  • Host-related variables are increasingly recognized as predictors of cancer outcomes.
  • The Host index (H-index) is a composite biomarker integrating immunological and nutritional parameters.
  • Its prognostic value in gallbladder cancer (GBC) requires further investigation.

Purpose of the Study:

  • To evaluate the H-index as a prognostic marker in patients with gallbladder cancer (GBC) undergoing curative resection.
  • To assess the association between the H-index and disease-free survival (DFS) and overall survival (OS).

Main Methods:

  • Retrospective cohort study of 241 curatively resected GBC patients.
  • Exclusion of patients who received neoadjuvant therapy, had metastatic disease, or incidental GBC.
  • Calculation and analysis of the H-index based on baseline neutrophil, lymphocyte, monocyte, platelet counts, hemoglobin, and albumin levels.

Main Results:

  • A higher H-index was significantly associated with worse disease-free survival (DFS) on both univariate and multivariate analyses.
  • A cut-off H-index of 1.31 differentiated 3-year DFS, with higher values predicting poorer outcomes.
  • The H-index did not show a significant association with overall survival (OS).

Conclusions:

  • The H-index is a potential prognostic marker for predicting recurrence in curatively resected GBC.
  • Host-related biomarkers, as captured by the H-index, influence outcomes in GBC.
  • Larger prospective studies are needed to validate these findings and their clinical utility.