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Updated: Jun 20, 2026

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

Published on: September 3, 2021

Liver transplantation for colorectal cancer with liver metastases.

Benjamin E Ueberroth¹, Michael Kriss², James R Burton²

¹Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, United States.

|January 21, 2025

Summary

Liver transplantation offers a survival benefit for patients with colorectal cancer liver metastases. Careful patient selection and adherence to specific criteria improve outcomes, making it a viable option for advanced disease.

Keywords:

chemotherapy colon cancer liver transplantation metastasis rectal cancer

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Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis

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Area of Science:

Hepatobiliary Surgery
Surgical Oncology
Transplantation Medicine

Background:

Liver transplantation has shown survival benefits for colorectal cancer (CRC) with liver metastases.
Advances in organ preservation expand transplantation eligibility for unresectable liver metastases.
Current data indicate comparable overall survival (OS) to general liver transplant recipients.

Purpose of the Study:

To evaluate the efficacy of liver transplantation for unresectable colorectal cancer liver metastases.
To identify key criteria for patient selection and improved outcomes.
To support policy changes regarding organ allocation for this patient group.

Main Methods:

Review of clinical trials and available literature on liver transplantation for CRC liver metastases.
Analysis of factors predicting outcomes, including primary tumor resection, neoadjuvant chemotherapy, and restaging.
Assessment of specific criteria such as carcinoembryonic antigen (CEA) levels and tumor size.

Main Results:

Improved outcomes are associated with R0 resection, 6-12 months of neoadjuvant chemotherapy, and negative extrahepatic disease on imaging.
Chemotherapy response predicts long-term outcomes; progression is a contraindication.
CEA ≤80 µg/L and largest tumor <5.5 cm correlate with better progression-free and OS.

Conclusions:

Liver transplantation provides superior progression-free and OS compared to chemotherapy alone for select CRC liver metastases patients.
Rigorous patient selection using imaging, laboratory, and clinical data is crucial.
Liver transplantation should be considered at active transplant centers for advanced CRC.