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Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

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Emerging Delivery Systems for Enabling Precision Nucleic Acid Therapeutics.

Xiaochun Bian¹, Liping Zhou¹, Zhiwei Luo¹

¹Beijing Key Laboratory for Bioengineering and Sensing Technology, Daxing Research Institute, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.

|January 21, 2025

Summary

Novel delivery systems enhance nucleic acid therapeutics for genetic diseases. These innovations overcome challenges like stability and targeting, paving the way for precision medicine advancements.

Keywords:

Clinical applications Delivery systems Drug delivery barriers Gene therapy Nucleic acid drugs Nucleic acid therapeutics Precision medicine Targeted delivery

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Published on: August 11, 2018

Area of Science:

Biomedical Engineering
Nanotechnology
Pharmacology

Background:

Nucleic acid therapeutics offer genetic-level disease treatment but face delivery challenges.
Stability, cellular uptake, and tissue targeting are key obstacles for nucleic acid drugs.
Existing delivery methods require enhancement for practical therapeutic applications.

Purpose of the Study:

To review various nucleic acid drug delivery systems.
To analyze barriers in nucleic acid drug delivery.
To summarize advancements in emerging delivery systems for precision medicine.

Main Methods:

Systematic review of nucleic acid drug delivery systems.
Analysis of challenges in stability, efficacy, and targeting.
Summary of research progress in viral, lipid, polymer, and nanoparticle-based systems.
Inclusion of exosomes, conjugates, and DNA nanostructures.

Main Results:

Various delivery systems (nanoparticles, exosomes, conjugates) improve nucleic acid drug stability, targeting, and half-life.
These systems show promise in treating genetic diseases, infections, cancer, and brain disorders.
Advancements integrate nanotechnology, biomaterials, and gene editing for enhanced efficacy.

Conclusions:

Innovative delivery systems are crucial for overcoming nucleic acid therapeutic limitations.
Emerging technologies are expanding the therapeutic potential of nucleic acid drugs.
Further development promises transformative impacts on precision medicine and disease treatment.