Effects of basic type of intermittent exotropia on myopic shift in children: a 12-month observational study
Jing-Xin Li1, Xiang-Xiang Liu1, Jie Hao1
1Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China.
Insights
Children with basic intermittent exotropia (IXT) experience faster myopia progression. Increased exodeviation angle correlates with greater myopia shift, suggesting a link between strabismus and refractive error development.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Myopia Research
Background:
- Intermittent exotropia (IXT) is a common childhood strabismus.
- The impact of IXT on myopia progression requires further investigation.
- Understanding this relationship is crucial for pediatric eye care.
Purpose of the Study:
- To investigate the effect of basic IXT on myopic shift in children over a 12-month period.
- To compare myopic progression in children with and without IXT, and after surgical correction.
- To identify clinical parameters associated with myopia progression in IXT patients.
Main Methods:
- Prospective study of 165 children (aged 4-15) divided into three groups: basic IXT, post-IXT surgery, and controls.
- Measurements included spherical equivalent (SE), axial length (AL), exodeviation, and binocular function at baseline and 12 months.
- Statistical analyses included univariate and multivariate linear regression to assess associations between IXT and myopic shift.
Main Results:
- Children with basic IXT showed significantly faster SE progression and AL elongation compared to controls.
- While post-surgery patients had less progression than IXT patients, the difference was not statistically significant.
- Increased exodeviation angle was significantly associated with both SE progression and AL elongation.
Conclusions:
- Basic IXT is associated with accelerated myopia progression in children.
- Surgical correction may slow myopia progression, but further research is needed to confirm statistical significance.
- The degree of exodeviation is a key factor influencing the rate of myopic shift in children with IXT.
Background:
To investigate the effect of basic intermittent exotropia (IXT) on myopic shift in children during 12-month follow-up.
Methods:
165 children aged 4-15 years were recruited prospectively in this study and divided into 3 groups: Group A, consisted of 64 patients with basic IXT without surgery; Group B, consisted of 51 patients 1-month after IXT-corrected surgery; and Group C, consisted of 50 patients without any form of strabismus. All patients underwent assessments of spherical equivalent (SE), axial length (AL), exodeviation, and binocular function relating to accommodation and convergence. Examinations were conducted at baseline and 12-month. SE and AL changes were compared among groups. Univariate and multivariate linear analyses were employed to investigate the association between myopic shift and IXT, as well as other clinical parameters.
Results:
Three groups showed comparable ages, genders and SEs at baseline (all P > .05). During 12-month follow-up, the rate of myopic shift varied among groups. Significant differences in SE progression (P = .006) and AL elongation (P = .014) between Group A and Group C were observed. Although SE progression and AL elongation in Group B were less than Group A, no significant differences were found (P = .125; P = .038). In the multivariate analysis, increases in exodeviation angle were significantly associated with both SE progression (β = 0.010, P = .041) and AL elongation (β = -0.005, P = .026). Each one prism diopter increase in the exodeviation angle was correlated with a 0.01D SE progression and a 0.005 mm AL elongation.
Conclusions:
Children with basic IXT exhibited faster myopia shift compared to those without strabismus. Although surgical correction of strabismus appeared to slow this process, the effect was not statistically significant. Furthermore, greater increase in exodeviation angle was associated with higher rate of SE progression and AL elongation.
Trial Registration:
The study was approved by the Ethics Committee of Beijing TongRen Hospital (approved number: TRECKY2020-142, approved date: 2020.10.30).
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