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Correlation Between the Koebner Phenomenon and Clinical Features in Vitiligo.
Xianfa Tang1,2,3, Cuilan Hao1,2,3, Min Fan1,2,3
1Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
Clinical, Cosmetic and Investigational Dermatology
|January 21, 2025
Summary
The Koebner phenomenon (KP) in vitiligo patients is linked to disease progression, acrofacial type, and more immune-related diseases. Identifying KP may indicate a more active and aggressive form of vitiligo.
Area of Science:
- Dermatology
- Autoimmune Diseases
- Clinical Research
Background:
- Vitiligo is a chronic autoimmune condition characterized by depigmentation.
- The Koebner phenomenon (KP) is the appearance of skin lesions at sites of trauma.
- Understanding KP's association with clinical features can aid in vitiligo management.
Purpose of the Study:
- To investigate the correlation between the presence of the Koebner phenomenon (KP) and clinical features in vitiligo patients.
- To determine if KP is associated with disease activity and specific clinical subtypes.
Main Methods:
- A retrospective analysis of 1472 vitiligo patients was conducted.
- Clinical data including age, disease duration, clinical type, and comorbidities were collected.
- Statistical analysis, including binary logistic regression, was used to assess associations with KP.
Main Results:
- Of 1472 patients, 19.70% exhibited KP.
- KP-positive patients showed significantly longer clinical course, higher rates of progressive stage, acrofacial type, comorbid immune-related diseases, and larger lesion areas (≥2%).
- Progressive stage, lesion area ≥2%, and comorbid immune-related diseases were significantly associated with KP presence.
Conclusions:
- The Koebner phenomenon in vitiligo is associated with clinical progression, acrofacial subtype, and comorbid immune-related diseases.
- KP may serve as a clinical indicator of disease activity and aggression in vitiligo.
- Recognizing KP's significance is crucial for effective disease management.
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