An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway

Area of Science:

• Molecular Biology
• Oncology
• Pharmacology

Background:

• The nuclear factor-kappa B (NF-κB) signaling pathway is crucial in regulating cell survival, growth, and migration.
• Dysregulation of NF-κB signaling contributes to uncontrolled cell proliferation, viability, movement, and invasion, driving tumor development.
• Plant-derived phytochemicals, particularly flavonoids, are recognized for their antioxidant, anti-inflammatory, antiviral, and antitumor properties.

Purpose of the Study:

• To outline the cancer-promoting role of the NF-κB pathway in tumor progression, drug resistance, angiogenesis, and metastasis.
• To summarize the anticancer potential of flavonoids through their specific targeting of the NF-κB pathway.

Main Methods:

• Review of current research on NF-κB signaling in cancer.
• Analysis of the mechanisms by which flavonoids exert anticancer effects, focusing on NF-κB inhibition.
• Comprehensive literature review on flavonoids as targeted cancer therapeutics.

Main Results:

• NF-κB pathway deregulation is implicated in critical aspects of cancer development and progression.
• Flavonoids demonstrate significant anticancer potential by suppressing NF-κB signaling.
• Flavonoids' antioxidative and immunomodulatory actions are key mechanisms for their antitumor effects.

Conclusions:

• The NF-κB pathway is a significant target for cancer therapeutics.
• Flavonoids represent a promising class of natural compounds for cancer treatment due to their ability to inhibit NF-κB signaling.
• Further research into flavonoids targeting NF-κB may lead to novel cancer therapies.