Seronegative Autoimmune Encephalitis With Rapidly Progressive Parkinsonism

Area of Science:

• Neurology
• Neuroimmunology
• Geriatric Medicine

Background:

• Seronegative autoimmune encephalitis is uncommon in elderly individuals.
• Rapidly progressive parkinsonism is an atypical presentation for autoimmune encephalitis.

Observation:

• An older patient exhibited worsening Parkinson's-like symptoms over one month.
• The patient's autoimmune antibody panel was negative.

Findings:

• Autoimmune encephalitis should be considered in older patients with rapidly progressive parkinsonism.
• Radiological findings are crucial for diagnosis when serological tests are negative.

Implications:

• This case broadens the differential diagnosis for parkinsonism in the elderly.
• Emphasizes the diagnostic utility of neuroimaging in suspected autoimmune encephalitis.
• Highlights the importance of a comprehensive diagnostic approach in atypical neurological presentations.