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Updated: Jun 1, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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A Comprehensive Appraisal of Bisbenzylisoquinoline Alkaloids Isolated From Genus Cyclea for Anticancer Potential

Alisha Valsan1,2, Vishnu K Omanakuttan1,2, Kokuvayil Vasu Radhakrishnan1,2

  • 1Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram, India.

Journal of Biochemical and Molecular Toxicology
|January 21, 2025
PubMed

Insights

Bisbenzylisoquinoline (BBIQ) alkaloids show significant anticancer potential, especially against multidrug resistance. Further research into these compounds, particularly from Indian Cyclea species, is crucial for developing new cancer therapies.

Area of Science:

  • Pharmacology
  • Natural Products Chemistry
  • Oncology

Background:

  • The search for novel anticancer lead compounds is ongoing due to cancer's complex etiology.
  • Multidrug resistance remains a critical challenge in cancer therapy.
  • Bisbenzylisoquinoline (BBIQ) alkaloids exhibit promising anticancer activities by targeting diverse signaling pathways.

Purpose of the Study:

  • To review the anticancer potential of BBIQ alkaloids, with a focus on those from Indian Cyclea species.
  • To highlight the therapeutic promise of BBIQ alkaloids in overcoming multidrug resistance.
  • To emphasize the need for further investigation into these natural compounds for cancer treatment.

Main Methods:

  • Literature review of existing studies on BBIQ alkaloids and their anticancer properties.
  • Identification and characterization of BBIQ alkaloids from various plant sources, including eight Indian Cyclea species.
  • Analysis of signaling pathways modulated by BBIQ alkaloids in cancer models.

Main Results:

  • Approximately 27 BBIQ alkaloids have been identified with demonstrated anticancer potential.
  • Several BBIQ alkaloids are currently undergoing clinical trials.
  • BBIQ alkaloids show efficacy in modulating diverse cancer-related signaling pathways and combating multidrug resistance.

Conclusions:

  • BBIQ alkaloids represent a promising class of natural compounds for cancer drug discovery.
  • Further exploration of BBIQ alkaloids, especially those from Indian Cyclea species, is warranted.
  • These compounds hold significant potential for developing novel therapeutic strategies against multidrug-resistant cancers.

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