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TYK2 :p.Pro1104Ala Variant Protects Against Autoimmunity by Modulating Immune Cell Levels

Maristella Steri1, Valeria Orrù1, Carlo Sidore1

  • 1Institute of Genetic and Biomedical Research (IRGB), Italian National Research Council (CNR), Monserrato, Sardinia, Italy.

Immunology
|January 21, 2025
PubMed
Summary

The TYK2:p.Pro1104Ala variant increases regulatory T cells and naive T and B lymphocytes, reducing immune activation. This mechanism explains its protective effect against autoimmune diseases.

Keywords:
TYK2autoimmunityimmune cell levelsimmunophenotypingnaïve cells

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