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Medications for Alcohol Use Disorder Are Increasingly Being Prescribed in American Patients With Advanced Liver
Abhishek Shenoy1, Venkata Sai Jasty2, Sarah Uttal1
1Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA.
None:
The number of alcohol use disorder patients with mild (n = 101) and severe alcoholic liver disease (n = 112) increased between 2013 and 2023 ( P = 0.06). Naltrexone was prescribed in 65%, acamprosate in 26%, and disulfiram in 9%. Internal medicine providers were the most frequent prescribers (51%), followed by psychiatry (30%) and gastroenterology/hepatology (9%) ( P = 0.001). Duration of use was longest with naltrexone compared with acamprosate and disulfiram (360 vs 251 vs 190 days, P = 0.032). The rate of alcohol use disorder medication discontinuation for adverse events was similar in both groups (14% vs 12%). Naltrexone, acamprosate, and disulfiram are increasingly being prescribed in American patients with mild and severe alcohol-related liver disease with similar tolerability and efficacy.
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