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Related Experiment Videos

[Is psoriasis an autoimmunologic disease?].

S Jabłońska, E H Beutner, M Jarzabek-Chorzelska

    Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
    |December 1, 1979
    PubMed
    Summary

    Psoriasis involves reversible T-lymphocyte defects and immune complexes of stratum corneum antibodies and antigens, causing "squirting papillae." Polymorphonuclear infiltrates play a key role in perpetuating this immune-mediated skin disease.

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    Immunopathological diagnosis of pemphigus foliaceus.

    Dermatology (Basel, Switzerland)·2002

    Area of Science:

    • Immunodermatology
    • Pathophysiology of Psoriasis

    Context:

    • Psoriasis is an active inflammatory skin condition.
    • T-lymphocyte dysfunction is observed in active psoriasis.
    • The pathogenesis involves immune complexes and polymorphonuclear infiltrates.

    Purpose:

    • To elucidate the immunological mechanisms underlying psoriasis.
    • To identify the role of immune complexes and cellular infiltrates in lesion development.
    • To explore therapeutic implications based on immunologic findings.

    Summary:

    • Defective T-lymphocyte function in psoriasis is transitional and reversible.
    • Immune complexes formed by stratum corneum antibodies and antigens, along with complement activation, cause characteristic skin phenomena like "squirting papillae".

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  • Early psoriatic lesions show abundant polymorphonuclear infiltrates, crucial for disease perpetuation.

    • Impact:

    • Understanding these mechanisms informs potential therapeutic strategies.
    • Therapeutic implications include polymorph depletion (e.g., peritoneal dialysis), removal of immune activators (e.g., treating infections), and topical treatments affecting stratum corneum antigenicity or exocytosis.