Clinical Trial: Precise Administration of Sucralfate Powder in Prevention of Delayed Postpolypectomy Bleeding. A...

Area of Science:

• Gastroenterology
• Endoscopic Procedures
• Surgical Complication Prevention

Background:

• Delayed postpolypectomy bleeding affects 1-2% of patients, rising to 6% for large polyps (>2 cm).
• Sucralfate is known for its mucosal protective and healing properties.

Purpose of the Study:

• To evaluate the efficacy of colonoscopic sucralfate powder spraying in preventing delayed postpolypectomy bleeding.
• To assess the safety and effectiveness of this prophylactic intervention.

Main Methods:

• A randomized controlled trial involving 160 patients undergoing colonoscopic polypectomy (polyp size ≥0.5 cm).
• Patients were randomized into two groups: one receiving prophylactic sucralfate powder spray (3 g) on polypectomy wounds, and a control group.
• Both groups received standard treatment for immediate bleeding and were monitored for delayed bleeding within 28 days.

Main Results:

• The sucralfate group showed significantly lower rates of delayed postpolypectomy bleeding (0% vs. 6.3%, P=0.029) and overt bloody stool (2.4% vs. 18.8%, P=0.001) compared to the control group.
• The duration of freedom from delayed bleeding was significantly longer in the sucralfate group (P=0.024).
• Multivariate analysis identified sucralfate spray as an independent protective factor against postpolypectomy overt bloody stool (RR=0.03, P=0.009).

Conclusions:

• Colonoscopic spraying of sucralfate powder is a safe and effective method for reducing the risk of delayed postpolypectomy bleeding.
• This intervention shows potential as a prophylactic measure against bleeding complications following colonoscopic polypectomy.